a strong trendp = 0.052
In CKD cells, this elevation persisted at 1- hour (+306%, post-hoc p = 0.047) and 7- hours post-stretch (+219%, post-hoc p = 0.004), with a strong trend toward an increase at 3 hours (+185%, post-hoc p = 0.052).
In CKD cells, this elevation persisted at 1- hour (+306%, post-hoc p = 0.047) and 7- hours post-stretch (+219%, post-hoc p = 0.004), with a strong trend toward an increase at 3 hours (+185%, post-hoc p = 0.052).
The group × time interaction did not reach statistical significance (Greenhouse–Geisser corrected p = 0.052), indicating that while temporal differences were observed within groups, the overall response to mechanical stretch was broadly similar between CKD and healthy control cells.
Post-hoc analysis revealed a near-significant two-fold decrease in MyoD mRNA expression following CE in the untrained state (post-hoc = 0.05), which was reversed following training, resulting in a significant increase compared with the untrained condition (post-hoc p = 0.01).