Effectiveness of a Fully Automated Mobile Therapeutic Versus a General Chatbot in Reducing Depression and Anxiety and Improving Well-Being: Feasibility Randomized Controlled Trial.

JMIR Ment Health · 2026 · PMC13102284 · PMID 42018980

Europe PMC DOI

hedged sentences

0.0500

closest p · 1.0× alpha

0.0800

boldest claim

The sentences

showed a trendP =.05actually significant

Logistic regression revealed that baseline symptom severity was not a significant predictor, although higher baseline ODSIS scores showed a trend toward predicting a lower likelihood of retention (OR=0.92; P =.05).

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a strong trendP =.08so close (0.05 < p ≤ 0.1)

This test revealed a strong trend suggesting that dropout rates were dependent on group assignment ( χ 2=5.14; P =.08).

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did not reach statistical significanceno p-value reported

The AI therapy group also showed trends toward greater improvement in anxiety symptoms (GAD-7: 1.98 point reduction, d =−0.37) and ODSIS depression functional impairment scores (1.13 point reduction, d =−0.25), although these did not reach statistical significance.

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