Deciphering novel genotypic biomarkers and functional alterations in double strand break repair pathways for Parkinson's disease.

Sci Rep · 2026 · PMC13102983 · PMID 41813791

Europe PMC DOI

hedged sentences

0.0000

closest p · 0.0× alpha

0.1763

boldest claim

The sentences

nominally significantp = 3.55 × 10−5actually significant

Nominally significant associations with PD risk were identified for four SNPs: XRCC6 rs5751129 ( p = 3.55 × 10−5), XRCC4 rs28360071 ( p = 0.0181), NBN rs2735383 ( p = 0.0213) and RAD50 rs17772583 ( p = 0.0411).

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did not reach statistical significancep = 0.1763not close (p > 0.1)

In contrast, for XRCC6 rs5751129, mRNA expression was slightly reduced in 14 CT carriers compared with 32 TT (wild-type) individuals, although this difference did not reach statistical significance ( p = 0.1763).

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a significant trendno p-value reported

This cumulative effect was further supported when combined individuals with one or two PD-susceptible genotypes (OR = 2.53, 95%CI = 1.21–5.27, p = 0.0165), and those with three or four susceptible genotypes (OR = 3.93, 95%CI = 1.83–8.43, p = 0.0004), with a significant trend across subgroups ( p for trend = 0.0009, Table 5 ).

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