Age-related transcriptional drift and physiological adaptation in long-living Ames dwarf skeletal muscle.

NAR Mol Med · 2026 · PMC13111926 · PMID 42051878

Europe PMC DOI

hedged sentences

0.0547

closest p · 1.1× alpha

0.0547

boldest claim

The sentences

near-significantP -value = 0.0547so close (0.05 < p ≤ 0.1)

Additionally, there was a near-significant effect of age within genotype (chi-square = 3.692, df = 1, P -value = 0.0547), with maximal grip strength observed at 6 months in early-old-aged dwarf mice.

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did not reach statistical significanceno p-value reported

Compared with middle-aged wildtype mice, old-aged wildtype mice showed positive enrichment of the SASP genes, but this enrichment did not reach statistical significance (Fig. 5A , P -adjusted value > 0.1, NES = 0.96).

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a strong trendno p-value reported

Early-old-aged dwarf mice also exhibited a strong trend toward increased grip strength with age.

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