SdLDL‑C/LDL‑C discordance as a practical surrogate for triglyceride‑associated cardiovascular risk: identification of at‑risk lipid phenotypes in the CHARLS prospective cohort.

Lipids Health Dis · 2026 · PMC13112678 · PMID 41845466

Europe PMC DOI

hedged sentences

0.1120

closest p · 2.2× alpha

0.1120

boldest claim

The sentences

failed to reach statistical significanceP = 0.112not close (p > 0.1)

After full adjustment, the association between isolated high sdLDL-C levels and CVD risk failed to reach statistical significance (HR = 1.152, P = 0.112).

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did not reach statistical significanceno p-value reported

Although a trend toward effect modification was observed for hypertension, it did not reach statistical significance ( P for interaction = 0.057).

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a significant trendno p-value reported

Cox proportional hazards models further revealed a graded association linking discordance categories to CVD risk, with a significant trend across groups ( P for trend = 0.040 in Model 4; Table 3 ).

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