Culture-Confirmed Bacterial Sepsis and Invasive Fungal Infection in Preterm Infants: NICU Resource Burden, Major Morbidity, and Caregiver Psychological Distress.

Diseases · 2026 · PMC13114302 · PMID 42041612

Europe PMC DOI

hedged sentences

0.0510

closest p · 1.0× alpha

0.4890

boldest claim

The sentences

approached significancep = 0.051so close (0.05 < p ≤ 0.1)

33.3%) and approached significance ( p = 0.051), indicating a potential association that may become clearer in larger samples.

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did not reach statistical significancep = 0.489not close (p > 0.1)

25.0%), but this trend did not reach statistical significance ( p = 0.489), likely reflecting limited power, especially in the candidemia subgroup.

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near-significantno p-value reported

Finally, the near-significant stepwise increase in severe IVH (6.8% → 19.4% → 33.3%) highlights a pattern that has been linked in other cohorts to infection-related hemodynamic instability and inflammatory injury, and multiple studies report worse neurodevelopment after neonatal sepsis in extremely preterm populations at 2 years of age [ 22 , 23 ].

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.