Elevated FGR protein expression identifies a high-risk subset of diffuse large B-cell lymphoma and a potential therapeutic target.

Front Oncol · 2026 · PMC13128391 · PMID 42078811

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0.0630

closest p · 1.3× alpha

0.0880

boldest claim

The sentences

did not reach statistical significanceP = 0.063so close (0.05 < p ≤ 0.1)

FGR-high expression was observed in 30 of 37 (81.1%) GCB cases and 34 of 54 (63.0%) non-GCB cases, although the difference did not reach statistical significance (P = 0.063).

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a strong trendP = 0.082so close (0.05 < p ≤ 0.1)

In multivariable Cox regression, high FGR remained independently associated with inferior 5-year PFS (HR 4.73, 95% CI 1.03-21.65; P = 0.045) and showed a strong trend toward inferior 5-year OS (HR 6.52, 95% CI 0.79-53.99; P = 0.082).

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showed a trendP = 0.088so close (0.05 < p ≤ 0.1)

In survival analyses, patients in the upper quartile of FGR expression showed a trend toward inferior OS compared with the remainder of the cohort (HR = 1.34, 95% CI 0.96-1.87; P = 0.088), while no association was observed for PFS (HR = 1.12, 95% CI 0.80-1.57; P = 0.510) ( Supplementary Figure 1 ). 3.3.

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