Postpartum breast cancer: evidence for a distinct phenotype.

In analyses of biomarker trends for ordinal categories of TSLB, 18 biomarkers were nominally significant, and CD20 ( P = 1.00 × 10 −3 ), CTLA4 ( P = 1.00 × 10 −3 ), PD-1 ( P = 1.00 × 10 −3 ), PR ( P = 1.00 × 10 −4 ), and PTEN ( P = 5.00 × 10 −4 ) remained significant after Bonferroni correction ( Table S6 ).

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Additional analyses In models additionally adjusted for BC molecular subtype, univariable P -values for CD20 remained significant and IDO-1, PTEN, and STING approached significance, and in multivariate analyses, fibronectin, GZMB, and SMA remained significant after adjusting for multiple comparisons.

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SIR analysis, including both parous and nulliparous women, identified 14 nominal biomarker associations and significant associations adjusted for multiple comparisons for SMA and an association approaching significance for GZMB.

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