Efficacy and safety of thoracoscopic photodynamic therapy combined with 5% ethanol-cisplatin intrapleural perfusion in the treatment of malignant pleural effusion in non-small cell lung cancer.

Although, after strict statistical correction, the survival difference between the PDT + E-Cis group and the IP-Cis group did not reach significance, a clear trend towards prolonged OS was observed (14.17 vs. 11.23 months, P = 0.033), accompanied by a significant improvement in ORR.

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The median OS (14.17 months) was significantly superior to that of the Control group (8.88 months, P < 0.001) and showed a trend towards prolongation compared to the IP-Cis group (11.23 months, P = 0.033).

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Post-hoc pairwise comparisons with Bonferroni correction showed that the PFS of the PDT + E-Cis group was significantly better than that of the Control group ( P = 0.005), while compared to the IP-Cis group, although numerically longer, the difference did not reach statistical significance ( P = 0.229); there was also no significant difference between the Control and IP-Cis groups ( P = 0.459).

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