Construction and external validation of a nomogram for predicting 10-year recurrence risk after radical resection in Chinese patients with stage III colorectal cancer.

Transl Cancer Res · 2026 · PMC13190854 · PMID 42180884

Europe PMC DOI

hedged sentences

0.0580

closest p · 1.2× alpha

0.0590

boldest claim

The sentences

showed a trendP=0.058so close (0.05 < p ≤ 0.1)

Even after multivariable adjustment, MAC still showed a trend toward increased recurrence risk (HR ≈1.41, P=0.058), while other rarer unfavorable subtypes (e.g., signet-ring cell carcinoma) demonstrated an even greater risk compared with conventional adenocarcinoma (HR ≈1.92, P=0.03).

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a near-significant trendP=0.059so close (0.05 < p ≤ 0.1)

Notably, the recurrence rate in N2 patients was 55.0%, compared with 30.4% in N1 patients, showing a near-significant trend (χ 2 =3.57, P=0.059).

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did not reach statistical significanceno p-value reported

After multivariable adjustment, positive CEA status (HR =1.45, P=0.10) and tumor diameter >3 cm (HR =1.26, P=0.08) did not reach statistical significance.

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an overall trendno p-value reported

In the external validation cohort, the 10-year cumulative recurrence probability was also close to 50%, showing an overall trend consistent with the SEER cohort, although with wider CIs due to the smaller sample size.

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