a strong trendp = 0.056
In the MMRd subgroup, LVSI showed a strong trend toward increased recurrence risk (OR 5.17, 95% CI 0.96–27.91, p = 0.056).
In the MMRd subgroup, LVSI showed a strong trend toward increased recurrence risk (OR 5.17, 95% CI 0.96–27.91, p = 0.056).
In the multivariate analysis, no variable retained independent statistical significance, although molecular classification and prognostic risk group showed a trend toward association with recurrence ( Table 4 ).
This is particularly relevant for the POLE-mutated subgroup and for stratified and multivariable analyses, where wide confidence intervals were observed, and some associations did not reach statistical significance.