Hnf1aos1 as a Metabolic Coordinator of Hepatic Lipid Homeostasis and Feedback Control.

Noncoding RNA · 2026 · PMC13214671 · PMID 42200947

Europe PMC DOI

hedged sentences

0.0621

closest p · 1.2× alpha

0.0745

boldest claim

The sentences

did not reach statistical significancep = 0.0621so close (0.05 < p ≤ 0.1)

The selective increase of triglycerides in knockdown livers produced an elevated triglyceride-to-cholesterol ratio (TG:TC = 6.1:1) compared with HFD/Scr mice (TG:TC = 4.0:1) ( Figure 2 H); however, this difference did not reach statistical significance (one-way ANOVA, p = 0.0621) and should be interpreted as a trend.

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a strong trendp = 0.0745so close (0.05 < p ≤ 0.1)

Cyp7a1 , which catalyzes the rate-limiting step in bile acid synthesis, was reduced in Chow/Kd mice with a strong trend toward statistical significance ( p = 0.0745) ( Figure 4 A).

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showed a trendno p-value reported

Serum cholesterol and LDL cholesterol levels showed a trend toward higher levels in HFD-fed groups than in chow-fed groups, but these differences did not reach statistical significance, and there was no significant difference between HFD/Kd and HFD/Scr mice (top panels).

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