An LDH-based prognostic model for extensive-stage small-cell lung cancer patients treated with chemo-immunotherapy and consolidative thoracic radiotherapy.

Front Endocrinol (Lausanne) · 2026 · PMC13229745 · PMID 42244956

Europe PMC DOI

hedged sentences

0.0010

closest p · 0.0× alpha

0.0790

boldest claim

The sentences

highly significantp < 0.001actually significant

Baseline LDH, analyzed as a continuous variable, retained a highly significant effect (adjusted HR 1.006 per U/L, 95% CI 1.003–1.009, p < 0.001).

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a strong trendp = 0.07so close (0.05 < p ≤ 0.1)

Notably, maintenance immunotherapy showed a strong trend: patients who did not continue immunotherapy had a higher risk of death (HR 1.64, 95% CI 0.96-2.81) with p = 0.07 in univariate analysis.

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did not reach statistical significancep=0.079so close (0.05 < p ≤ 0.1)

In contrast, the association between maintenance immunotherapy and overall survival was attenuated and did not reach statistical significance in the imputed analysis (HR 0.543, 95% CI 0.273–1.079, p=0.079).

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showed a trendno p-value reported

Our cohort showed a trend toward worse survival with higher SII, consistent with prior studies ( 12 ).

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