Fluconazole-induced liver injury in patients with pulmonary cryptococcosis: a comprehensive study integrating clinical cohort analysis, network toxicology, molecular docking, and transcriptomics.

Antimicrob Agents Chemother · 2026 · PMC13231873 · PMID 42003579

Europe PMC DOI

hedged sentences

0.0760

closest p · 1.5× alpha

0.0760

boldest claim

The sentences

marginal significanceP = 0.076so close (0.05 < p ≤ 0.1)

Notably, the middle ALP tertile showed significant association (aRR 3.53, 95% CI 1.23–10.10; P = 0.019), whereas the upper tertile exhibited marginal significance (aRR 2.62, 95% CI 0.91–7.60; P = 0.076) ( Fig. 5B ).

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approaching significanceno p-value reported

A higher discontinuation rate was observed in patients with HT, with symptoms approaching significance (10.3% vs 0%; FDR-adj.

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did not reach statistical significanceno p-value reported

showed a trendno p-value reported

Although neutropenia showed a trend toward higher prevalence in the HT group (10.3% vs 0%), this difference did not reach statistical significance (FDR-adj.

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