Comparative Analysis of Retinal Structure and Function in Female Carriers of Choroideremia and X-Linked Retinitis Pigmentosa.

BCVA did not differ significantly between CHM severity groups, although the mild versus severe comparison approached significance ( P = 0.070, LMM).

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For IRT, no differences were observed at the fovea (0–1 mm), whereas significant reductions were present at the inner macula (1–3 mm) between all groups ( P < 0.05, LMM) and at the outer macula (3–6 mm) between mild versus intermediate ( P = 0.003, LMM) and mild versus severe ( P < 0.001, LMM), with the intermediate versus severe difference approaching significance ( P = 0.074, LMM).

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29 Age-matched analyses showed a trend toward faster BCVA decline and significantly greater retinal thinning across multiple zones in CHM compared to XLRP, mirroring prior OCT follow-up where XLRP carriers exhibited relatively smaller mean changes, particularly in the outer retina. 6 , 30 Conversely, ERG amplitudes were lower in XLRP.

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