Integration of Circulating Immune Checkpoint Proteins and Osteopontin Refined Risk Stratification in Osteosarcoma.

Cancers (Basel) · 2026 · PMC13255615 · PMID 42279285

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nominally significantno p-value reported

Both markers demonstrated nominally significant differential expression and consistent survival associations and were therefore prioritized to construct the two-marker ICP2 signature.

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did not reach statistical significanceno p-value reported

showed a trendno p-value reported

sOPN showed a trend toward higher levels in advanced disease but did not reach statistical significance.

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