Detection and prognostic role of circulating cancer-associated fibroblasts in the blood of melanoma patients.

Front Cell Dev Biol · 2026 · PMC13265522 · PMID 42306301

Europe PMC DOI

hedged sentences

0.0710

closest p · 1.4× alpha

0.0710

boldest claim

The sentences

a strong trendp = 0.071so close (0.05 < p ≤ 0.1)

With respect to OS, we observed a statistically significantly higher OS probability in patients with low S100B concentrations (p = 0.0094) and a strong trend of a longer OS in patients with non-elevated LDH levels (p = 0.071) ( Supplementary Figures S1C, S1D ).

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showed a trendno p-value reported

A higher mean number of cCAFs was detected and showed a trend toward shorter progression-free survival.

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did not reach statistical significanceno p-value reported

The combination of CTCs with S100B and LDH showed a trend of an increased risk stratification for PFS in patients with high CTCs and high S100B or high LDH levels, compared to the other combinations, but did not reach statistical significance ( Figures 4C,D ).

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