Characteristics, treatment regimens, and outcomes of patients with true extramedullary multiple myeloma: a real-world monocentric analysis.

Ann Hematol · 2026 · PMC13272244 · PMID 42303922

Europe PMC DOI

hedged sentences

0.0540

closest p · 1.1× alpha

0.0570

boldest claim

The sentences

did not reach statistical significancep = 0.054so close (0.05 < p ≤ 0.1)

Based on these findings, we exploratorily categorized anatomical sites into a three-tiered risk grouping, which revealed a stepwise gradient that did not reach statistical significance ( p = 0.054).

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a near-significant trendp = 0.057so close (0.05 < p ≤ 0.1)

Patients with HR lesions exhibited a near-significant trend toward shorter survival from EMD occurrence compared with those without HR involvement (17 months, 95% CI 11–34 vs. 40 months, 95% CI 28–53; p = 0.057).

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showed a trendno p-value reported

Survival varied by anatomical site: central nervous system (CNS), pulmonary, and retroperitoneal involvement showed a trend toward inferior survival, whereas lymph node involvement was associated with significantly longer survival in exploratory analyses ( p = 0.011).

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