Efficacy and safety of radiotherapy combined with chemoimmunotherapy versus chemoimmunotherapy alone as first-line treatment for metachronous oligorecurrent esophageal squamous cell carcinoma.

Front Oncol · 2026 · PMC13284883 · PMID 42339114

Europe PMC DOI

hedged sentences

0.0980

closest p · 2.0× alpha

0.1630

boldest claim

The sentences

did not reach statistical significanceP = 0.098so close (0.05 < p ≤ 0.1)

However, PFS tended to be longer in the sequential group, although the difference did not reach statistical significance (mPFS: 17.3 months [95% CI: 9.5–25.1] vs. 13.3 months [95% CI: 8.4–18.1]; P = 0.098) ( Figure 3 ).

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showed a trendP = 0.163not close (p > 0.1)

The concurrent group showed a trend toward higher incidence of G3+ pneumonitis compared to the sequential group (17.9% [12 of 67] vs. 5.7% [2 of 35], P = 0.163).

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borderline non-significantno p-value reported

RCIT was associated with significantly longer progression-free survival (PFS) than CIT, while overall survival (OS) showed a borderline non-significant trend favoring RCIT.

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