Effect of combined aspirin and statin therapy on mortality reduction in sepsis-induced myocardial injury.

In direct comparisons between the active treatment groups, combined therapy showed a trend toward lower mortality compared with aspirin monotherapy at 28 days (HR 0.52, 95% CI: 0.27-1.00, P = 0.05), with significant benefit at 90 days (HR: 0.47, 95% CI: 0.27-0.83, P < 0.01) and 1 year (HR: 0.59, 95% CI: 0.39-0.91, P = 0.02).

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Although no significant interactions were observed for any of the subgroups, a suggestive trend was noted between ventilated and non-ventilated patients with the combination therapy appeared to be more beneficial in ventilated patients.

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The individual effects of aspirin (HR: 0.723, 95% CI: 0.508-1.029, P = 0.071) and statin (HR: 0.752, 95% CI: 0.486-1.164, P = 0.199) did not reach statistical significance.

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