Integrated Multi-Omics Analysis Reveals an HCMV-Associated Late-Gene Signature Associated with Poor Survival in Pediatric Group 3 Medulloblastoma

Biomedicines · 2026 · PMC13296392

Europe PMC

hedged sentences

0.1750

closest p · 3.5× alpha

0.1750

boldest claim

The sentences

did not reach statistical significancep = 0.175not close (p > 0.1)

However, these differences did not reach statistical significance following multiple-comparison correction (Kruskal–Wallis p = 0.175; adjusted pairwise p = 0.428) ( Supplementary Material S2 ). 3.2.3.

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a clear trendno p-value reported

76 months, p = 0.065), a clear trend toward poorer outcome was observed ( Figure 6 , lower panel).

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showed a trendno p-value reported

Across medulloblastoma molecular subgroups, Group 3 tumors showed a trend toward higher composite expression of the HCMV-associated late-gene signature ( UL76 , UL88 , UL99 ) than WNT tumors (mean rank: 17.23 vs. 7.33).

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