Adjuvant Approaches in Fully Resected Stage III and IV Cutaneous Melanoma: Where Are We Now?

Cancers (Basel) · 2026 · PMC13296865

Europe PMC

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approached significanceno p-value reported

a strong trendno p-value reported

Moreover, this regimen showed a strong trend that approached significance in terms of median RFS (4.5 vs. 2.5 years; HR 0.85; p 0.065).

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a positive trendno p-value reported

These patients have a more unfavorable prognosis, which increases the likelihood of identifying a positive trend in an effective treatment, thereby confirming the crucial role of patient selection in postsurgical strategies.

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did not reach statistical significanceno p-value reported

While the analysis showed that the risk of death was 20% lower, this benefit did not reach statistical significance ( p 0.06) [ 48 ].

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