Barely Significant
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Multi-Chamber Reverse Remodeling and Hemodynamic Force Realignment After SGLT2 Inhibitor Initiation in Real-World Heart Failure.

J Cardiovasc Dev Dis · 2026 · PMC13300219 · PMID 42346480

Europe PMCDOI
3
hedged sentences
0.2100
closest p · 4.2× alpha
0.3310
boldest claim

The sentences

did not reach statistical significancep = 0.21not close (p > 0.1)
NYHA Class improved, with a reduction in the portion of patients in higher classes (NYHA Class > II), decreasing from 27% to 18%, although it did not reach statistical significance probably due to the small sample size ( p = 0.21).

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showed a trendp = 0.331not close (p > 0.1)
LA-ESV did not significantly change even though it showed a trend in decreasing starting from 76 mL (IQR: 57–97) to 74 mL (IQR: 59–97) ( p = 0.331).

also in 33,481 other papers

near-significantno p-value reported
Nevertheless, the near-significant associations observed for systolic and diastolic HDFs ratios in exploratory analyses may suggest a potential relationship between intraventricular flow realignment and reverse remodeling.

also in 1,659 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.