near-significantp = 0.091
In the MTX subgroup, both sides declined over time, with a significant left-sided decrease (25.40 ± 9.86% to 12.80 ± 6.94%, p = 0.043) and a near-significant right-sided decrease ( p = 0.091) ( Figure 4 , Table 4 ).
In the MTX subgroup, both sides declined over time, with a significant left-sided decrease (25.40 ± 9.86% to 12.80 ± 6.94%, p = 0.043) and a near-significant right-sided decrease ( p = 0.091) ( Figure 4 , Table 4 ).
Left-sided CRC declined from 27.60 ± 13.46% to 22.50 ± 19.33%, but the change did not reach statistical significance in the whole group ( p = 0.144).
Results: Inflammatory markers and lipid profiles showed a trend toward improvement, though changes were not statistically significant, except for a significant increase in vitamin D ( p < 0.001) and a decrease in Disease Activity Score in 28 Joints (DAS28) scores ( p < 0.001).