The Hydroxyurea Absorption Phenotype: A Key PK/PD Determinant in Sickle Cell Disease Treatment.

84.3 ± 11.731 fL, p < 0.0001, Figure 5 a) and a strong trend towards higher HbF percentages (16.7 ± 9.89% vs. 13.9 ± 8.04%, p = 0.0835, Figure 5 b) compared to slow absorption (T max ≥ 1 h).

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Regarding total drug exposure, a trend toward higher AUC values was observed in rapid absorbers compared to slow absorbers, although this difference did not reach statistical significance, consistent with previously published data.

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Total exposure also showed a significant trend toward higher values in rapid profiles compared to slow profiles, although the difference was not statistically significant ( p = 0.0699 and p = 0.1756 for the AUC 0–6h and AUC inf , respectively) ( Figure 1 d,e).

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