DEK Loss Induces Task-specific Deficits in Learning and Memory and Reprograms the Hippocampal Transcriptome in Mice.

8 D), a strong trend toward increased Rspo1 expression ( t (9.31) = 1.97, p = 0.07; Fig. 8 E), and significantly increased Rgs6 expression ( t( 9.09) = 2.34, p < 0.05; Fig. 8 F), with no corresponding genotype-dependent differences detected in males for any of these genes.

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Further analyses of each day showed a trend on day 3 ( p = 0.096) and a significant effect on day 5 ( p = 0.0220) with female Dek cKO mice having longer latencies during reversal learning.

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In males, Dek cKO mice exhibited less freezing than WT mice; however, this difference did not reach statistical significance but showed a trend toward reduced contextual memory in cKO males ( p = 0.057; Supplementary Fig.

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