Association between serum vitamin B<sub>6</sub> levels and depression in adults: a cross-sectional National Health and Nutrition Examination Survey (NHANES) study.

A recent double-blind randomised controlled trial in young adults reported that 1 month of high-dose vitamin B 6 supplementation (100 mg/day) reduced self-reported anxiety and showed a trend towards reduced depressive symptoms compared with placebo, consistent with a role of vitamin B 6 in enhancing GABAergic inhibition ( 16 ) .

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However, these associations failed to reach statistical significance in specific populations, including other Hispanic and other racial categories for both metabolites and among individuals with liver disease for PA.

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In the fully adjusted model (model 2), compared with participants in the lowest quartile (Q1 <15·70 nmol/L), those in Q2 (15·70–24·80 nmol/L), Q3 (24·80–49·42 nmol/L) and Q4 (≥49·42 nmol/L) demonstrated odds ratios of 0·94 (95 % CI: 0·79, 1·12, P = 0·47), 0·86 (95 % CI: 0·71, 1·04, P = 0·12) and 0·80 (95 % CI: 0·65, 0·98, P < 0·05), respectively, with a significant trend across quartiles ( P -trend <0·001) ( Table 3 ).

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