Synovial tissue response to rituximab: mechanism of action and identification of biomarkers of response.

There was a highly significant decrease in serum levels of IgM-RF at 16 (p = 0.006) and 24 weeks (p<0.001) after treatment ( fig 1 ).

also in 132,142 other papers

The reduction of macrophages also showed a trend for predicting clinical improvement at week 24 in the univariate analysis (p = 0.051), but when analysed together with the decrease in plasma cells in a multiple linear regression model, it was not an independent predictor of the decrease in DAS28 (p = 0.216, partial correlation 0.399).

also in 53,322 other papers

On the group level this change did not reach statistical significance due to the variability of the response.

also in 111,027 other papers

There was no statistically significant additional reduction of synovial B cells at 16 weeks on the group level, but there was a clear trend towards more pronounced B cell depletion in 7 of the 15 patients who had persistent B cells at week 4 (median 39 cells/mm 2 (IQR 12–89) and 4 (0–22), at respectively 4 and 16 weeks after rituximab infusion).

also in 19,460 other papers