Age of onset in concordant twins and other relative pairs with multiple sclerosis.

Thus, the difference predicted by the a priori hypothesis that the correlation would be higher for maternal versus paternal half siblings was found but did not reach statistical significance ( t = 1.39, df = 27, P = 0.088).

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Among females, sporadic cases showed a trend toward an older mean age of onset compared with familial cases by about half a year, but this did not reach significance ( t = 1.838, df = 1,838, P = 0.033).

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The intraclass correlation coefficient for the paternal uncle-nephew pairs ( r = 0.65, n = 12, F = 4.64, P = 0.007, 95% confidence interval: 0.17, 0.88) and the combined paternal uncle-niece/nephew pairs ( r = 0.25, n = 43, F = 1.68, P = 0.047, 95% confidence interval: −0.05, 0.51) were nominally significant.

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