Interaction between two independent CNR1 variants increases risk for cocaine dependence in European Americans: a replication study in family-based sample and population-based sample.

Neuropsychopharmacology · 2009 · PMC2879626 · PMID 19052543

Europe PMC DOI

hedged sentences

0.0030

closest p · 0.1× alpha

0.0600

boldest claim

The sentences

highly significantP =0.003actually significant

In the global haplotype association test, the SNP8-containing haplotype showed a highly significant association with CIP ( P =0.003), which remained significant after correcting for multiple testing (with α=0.017).

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nominally significantP =0.015actually significant

Associations of CNR1 with CIP in EA family sample For CIP, nominally significant association signals were observed at two SNP8-linked loci, i.e., rs1049353 (SNP7) ( P =0.015) and rs2146274 (SNP10) ( P =0.010).

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did not reach statistical significanceP =0.060so close (0.05 < p ≤ 0.1)

The third most significant CD association signal was seen for rs6454674 (SNP3), though this did not reach statistical significance ( P =0.060).

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showed a trendno p-value reported

Through permutation, haplotype trend regression (HTR) analysis using the Powermarker program showed a trend-level possible association between CD and the global haplotypes composed of these two SNPs ( P global = 0.069).

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.