Significant association of KIR2DL3-HLA-C1 combination with cerebral malaria and implications for co-evolution of KIR and HLA.

PLoS Pathog · 2012 · PMC3297587 · PMID 22412373

Europe PMC DOI

hedged sentences

0.0100

closest p · 0.2× alpha

0.0100

boldest claim

The sentences

did not reach statistical significanceP >0.01actually significant

However, this did not reach statistical significance ( P >0.01).

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failed to reach statistical significanceP = 0.15not close (p > 0.1)

showed a trendno p-value reported

This is also supported by the observations that HLA-C1 in combination with KIR2DL2, another HLA-C1 receptor, showed no significant association with cerebral malaria, and in HLA-C1 positive individuals, KIR2DL3 positivity showed a trend for association with cerebral malaria ( Table 2 ), although this failed to reach statistical significance (OR = 1.89, 95%CI = 0.82–4.37, P = 0.15).

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