Amerind ancestry, socioeconomic status and the genetics of type 2 diabetes in a Colombian population.

BMI is also strongly correlated with SES ( Figure 2 ) but the association of BMI with disease remains highly significant even after accounting for SES and ancestry ( c BMI = 0.09241, P = 1.34 × 10 −6 ).

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Nominally significant association (P<0.05) was observed for markers in: TCF7L2, RBMS1, CDKAL1, ZNF239, KCNQ1 and TCF1 and a significant bias (P<0.05) towards OR>1 was observed for markers selected from previous T2D genome-wide association studies, consistent with a role for Old World variants in susceptibility to T2D in Latin Americans.

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Most likely the excess frequency of the risk allele at many of the markers tested did not reach statistical significance due to insufficient power to detect the small effects associated with certain variants.

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The Antioquian sample showed a trend towards higher BMI with increasing number of copies of the previously reported associated allele, although not reaching statistical significance (TT: 26.35, AT:26.74, AA: 26.82; P = 0.14).

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