In vivo efficacy of the histone deacetylase inhibitor suberoylanilide hydroxamic acid in combination with radiotherapy in a malignant rhabdoid tumor mouse model.

After a follow-up of > 40 days our data showed a trend towards slower tumor progression in the combined treatment group compared to xenotransplants treated with XRT alone, but this was not statistically significant in Cohort I treated with single-dose XRT and SAHA for 8 days ( p = 0.3) (Figure 1a ).

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However, this trend failed to reach statistical significance in both cohorts.

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We observed a strong trend towards a lower proliferation activity in the combination groups compared to the XRT alone groups.

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