Minocycline corrects early, pre-plaque neuroinflammation and inhibits BACE-1 in a transgenic model of Alzheimer's disease-like amyloid pathology.

J Neuroinflammation · 2012 · PMC3352127 · PMID 22472085

Europe PMC DOI

hedged sentences

0.0800

closest p · 1.6× alpha

0.0800

boldest claim

The sentences

a strong trendP = 0.08so close (0.05 < p ≤ 0.1)

Though a strong trend was observed towards reduction ( P = 0.08 and 0.09, respectively), this did not reach significance (Figure 2F ).

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did not reach statistical significanceno p-value reported

Given the relatively high variability of the data, these changes did not reach statistical significance; however, they support the notion of a pro-inflammatory state in these brains.

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showed a trendno p-value reported

IL-1β showed a trend towards up-regulation which did not reach significance (Figure 1C ).

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.