Preoperative administration of etoricoxib in patients undergoing hip replacement causes inhibition of inflammatory mediators and pain relief.

Tissue IL6 concentrations changed significantly over time ( p < 0.001), but the ‘treatment’ effect failed to reach statistical significance (effect treatment: p = 0.073; interaction: p = 0.084; descriptive data: see in Table 3 ).

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Similarly, the effects of etoricoxib administration on other parameters, including pain at rest, pain at movement, etc., showed a trend in favour of etoricoxib administration, but did not reach significance (compare Table 4 ). 4.

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The differences did not reach statistical significance.

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