Dabigatran 150 mg was found to have an increased rate of myocardial infarction (0.74%) when compared with warfarin (0.53%/year), although this effect did not reach statistical significance (RR 1.38, 95% CI 1–1.91, p=0.04).
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The sentences
Apixaban is the only new agent which demonstrated a statistically significant reduction in all-cause mortality compared to warfarin, although dabigatran 150mg BD and rivaroxaban also showed a trend towards reduction in the risk of death.
There was a trend towards a reduction in all-cause mortality with dabigatran, which approached significance in the high-dose dabigatran group.