Monocytes from depressed patients display an altered pattern of response to endotoxin challenge.

At baseline, cytokine gene expression was markedly increased in drug-naïve MDD patients compared to healthy controls; however, because of the much higher variability of this parameter compared to both PGE2 and COX-2, the difference did not reach statistical significance ( Fig. 4 and 5 ).

also in 111,027 other papers

Likewise, the high variability prevented to show a significant difference between IL-1 β and -6 mRNA levels assessed in patients at time 0 and after FU, although a strong trend to a reduction was observed ( Fig. 4 and 5 ).

also in 5,725 other papers

Such blunted prostanoid production was paralleled by a reduction in COX-2 gene expression, whereas other pro-inflammatory mediators, namely interleukin-1β (IL-1 β) and -6 (IL-6) showed a trend to increased gene expression.

also in 53,322 other papers