Mutation of the fiber shaft heparan sulphate binding site of a 5/3 chimeric adenovirus reduces liver tropism.

For other tissues, capsid mutations or coagulation factor depletion did not lead to significant differences although there was a strong trend of lower tumor, lung, kidney and also heart transduction with Ad5/3lucS* as compared to Ad5/3luc1 ( Fig. 5B, 5D-5F ).

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However, data from tumor, lung and kidney tissue homogenates indicated a clear trend of lower level of gene expression by the KKTK-mutated virus than by the control viruses.

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Indeed, both tests showed a trend of lower Ad5/3lucS* content in hepatocytes at both investigated early time points.

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