The small molecule Wnt signaling modulator ICG-001 improves contractile function in chronically infarcted rat myocardium.

Although the calculated differences were not statistically significant within our experimental group size, there was a clear trend towards increased Gdf15 , Kit , Sdf1 and Fgf2 expression with ICG-001 treatment at both day 7 and day 10 ( Figure 6C ), consistent with our in vitro results.

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However, these changes failed to reach statistical significance.

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The ICG-001 group showed a trend towards preserving cardiac morphology in regards to left ventricular cavity volume, infarct size, wall thinning ratio, and expansion index ( Figure 5C ).

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