There was a significant trend toward increased CSF levels of endostatin after TBI versus control from 72 h after injury.
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Endostatin/collagen XVIII is increased in cerebrospinal fluid after severe traumatic brain injury.
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Death group showed a trend toward increased CSF concentrations of endostatin/collagen XVIII after TBI versus survival group, which was especially significant at day 3 ( P = 0.026) and day 5 ( P = 0.001), although this did not reach statistical significance at 24 h and 7 days after trauma ( Table 2 and Figure 2(a) ).