The CLU SNP (rs11136000) showed a trend toward an association in ADNI-2/GO, but showed no pattern in the ADNI-1 dataset.
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The sentences
The other BIN1 SNP (rs744373) also interacted with PICALM although the effect did not reach statistical significance ( Figure 1 ).
The other nominally significant interactions included CD2AP (rs9296559) x PICALM (rs3851179), CLU (rs11136000) x PICALM (rs3851179), and CLU (rs11136000) x MS4A6A (rs610932).