A broad phenotypic screen identifies novel phenotypes driven by a single mutant allele in Huntington's disease CAG knock-in mice.

In the dark-light box, HdhQ111 /+ mice showed a trend towards an increased number of light box entries (males: Hdh+/+ 13.8±1.0, HdhQ111 /+ 15.7±1.4; females: Hdh+/+ 1.57±0.97, HdhQ111/+ 18.8±1.62; ANOVA genotype effect p=0.08), indicating reduced anxiety compared to wild-type mice and consistent with findings in the open field arena.

also in 53,322 other papers

Males also showed a trend towards increased TV at rest, but this did not reach statistical significance, likely because of the small number of mice that actually showed resting behavior ( Table S8 ).

also in 111,027 other papers

We have therefore reported both results with nominally significant p values, as well as those that do not reach statistical significance but which may be of interest in the context of other data presented here or elsewhere.

also in 7,732 other papers