IL-4 suppresses the responses to TLR7 and TLR9 stimulation and increases the permissiveness to retroviral infection of murine conventional dendritic cells.

Although we observed a strong trend of inhibition, the differences did not reach statistical significance because of variations between experiments.

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In the two independent cultures that we have tested ( Figure S2 ), we found a clear trend of IL-4 strongly suppressing both IL-12p70 and TNFα induced by CpG (data not shown) and R848 ( Figure S2 ), suggesting that IL-4 suppression of these cytokines is probably affecting both IFN and NFκ-B pathways.

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