However, in the sirolimus group, after a median followup of 16.6 months in patients with recurrence, the mean fibrosis scores on serial biopsies were significantly lower and the change in mean activity showed a decrease that approached significance [ 56 ].
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The Role of mTOR Inhibitors in Liver Transplantation: Reviewing the Evidence.
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In addition, although patient survival rates were comparable in both groups, a Kaplan-Meier survival analysis showed a trend towards better survival in the sirolimus group.
In three of these variable-quality studies, the incidences of anemia, leukopenia, and thrombocytopenia in the everolimus groups were higher than in the control groups, although differences did not reach statistical significance [ 52 , 87 , 96 ].