Evidence for a prosurvival role of alpha-7 nicotinic acetylcholine receptor in alternatively (M2)-activated macrophages.

Physiol Rep · 2013 · PMC3970735 · PMID 24744866

Europe PMC DOI

hedged sentences

0.0700

closest p · 1.4× alpha

0.0900

boldest claim

The sentences

showed a trendP = 0.07so close (0.05 < p ≤ 0.1)

In the presence of the STAT3 inhibitor (25 μ mol/L), nicotine treatment consistently showed a trend toward protection against thapsigargin‐induced apoptosis ( P = 0.07) which, although not reaching statistical significance, suggests that other nAChRs may exert a protective action through STAT3‐independent mechanisms.

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did not reach statistical significanceP = 0.09so close (0.05 < p ≤ 0.1)

Although a trend toward a protective effect of nicotine remained in α 7 −/− ‐M2 BMDMs, it did not reach statistical significance ( P = 0.09); importantly, the proapoptotic effect of thapsigargin was not statistically different between α 7 +/+ ‐ versus α 7 −/− ‐M2 BMDMs ( P = 0.17).

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a marked trendno p-value reported

Exposing macrophages to nicotine or PNU‐282987 under ER stress conditions resulted in a marked trend toward upregulation of Bcl‐2, although it did not reach statistical significance.

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