A trial in Uganda comparing rectal AM with intravenous quinine showed a trend towards faster parasite clearance and faster time to defervescence.
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Artesunate: The Best Drug in the Treatment of Severe and Complicated Malaria.
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The sentences
However, these results failed to reach statistical significance to reduce death [ 29 ] and rectal AS may well fare better [ 22 ].
The treatment effect was similar in children compared with adults but they constituted a much smaller group and results did not reach statistical significance [ 20 ].