Novel isoforms of heat shock transcription factor 1, HSF1γα and HSF1γβ, regulate chaperone protein gene transcription.

Although this was not statistically significant, we observed a clear trend for this synergistic enhancement of transcription induction for all three HSP genes ( Fig. 6 , B , D , and F ).

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Expression of a combination of the Hsf1 α and Hsf1 β isoform in a ratio of about 2:1 (see above) resulted in a highly significant synergistic induction after heat shock when compared with the signal for the individual isoforms ( Fig. 6 H , compare Hsf1 α and Hsf1 β with Hsf1 α,β co-expression).

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There was no significant difference in luciferase signal between the individual isoforms, although the α isoform showed a trend toward higher activity ( Fig. 6 H , individual isoforms).

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We also observed a similar pattern of Dnajb1 expression, although this did not reach statistical significance ( Fig. 6 C ).

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