Wound administration of M2-polarized macrophages does not improve murine cutaneous healing responses.

The same trend was observed for the M2c group, though differences were borderline non-significant (p = 0.073).

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Chemokine analysis indicated that while CXCL1 levels did not vary between groups, levels of CXCL2 were increased in M2a and M2c wounds, although differences did not reach statistical significance ( Fig. 5C ).

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M2 macrophage injected wounds showed a trend towards increased fibrin deposition and presence of erythrocytes in the wound bed, indicative of increased vessel leakage, and suggesting that these wounds might be at an earlier stage of healing compared to salines and M0 controls (graph; Fig 6B ).

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