Epiplakin deficiency aggravates murine caerulein-induced acute pancreatitis and favors the formation of acinar keratin granules.

Although the differences for wild-type and EPPK −/− mice were not significant, the amylase values at the six hours timepoint showed a clear trend towards higher levels in EPPK −/− mice ( Fig. 4K ). 24 hours after induction of pancreatitis, serum lipase and amylase levels had returned to almost basal levels, and histopathology showed no significant differences between EPPK −/− mice and their littermates ( Fig. 4G, H, I, J, K ).

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In addition, edema and inflammation both showed a trend towards elevated scores nine hours after induction of pancreatitis in EPPK −/− mice; however, the difference did not reach statistical significance with p = 0.08 and p = 0.16, respectively ( Fig. 4I ).

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