By Fisher's exact test, the difference in diabetes frequency did not reach statistical significance (p = 0.09).
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Raloxifene prevents skeletal fragility in adult female Zucker Diabetic Sprague-Dawley rats.
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Discussion This study showed that raloxifene treatment in female ZDSD rats improved blood glucose levels and showed a trend for prevention of type 2 diabetes while imparting a beneficial effect on bone material properties.
The effect of raloxifene on bone toughness was significant only for the femur, representing an effect on cortical bone, but a near-significant trend for greater toughness with raloxifene treatment was also observed for the distal femur by RPC, indicating a possible effect on cancellous bone as well.